Synthesis and Antimicrobial Activities of N4-(2-Acetoxyethoxymethyl)thiosemicarbazones and N3-(2-Acetoxyethoxymethyl)thioureas

Add time:07/12/2019    Source:sciencedirect.com

A series of thiosemicarbazones and thioureas having an open-chain analogue of the ribosyl group, the 2-acetoxyethoxymethyl moiety, has been synthesized. Significant growth inhibitory activity versus gram-positive and gram-negative organisms, a yeast, and a mold has been found with the 2-acetoxyethoxymethyl derivatives of N-alkyl-aryl-, and heteroaryl-thiosemicarbazones and thioureas. The molecules may function as inhibitors of ribonucleotide reductase or in utilization of the carbamyl group in pyrimidine biosynthesis.

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