A convergent synthesis of poststatin (cas 135219-43-1): Application of the acyl cyanophosphorane coupling procedure in the formation of a peptidic α-keto amide

Add time:08/11/2019    Source:sciencedirect.com

A convergent synthesis of the pentapeptide poststatin has been developed. The key step involves oxidative cleavage of an acyl cyanophosphorane. The resulting α,β-diketo nitrile is then coupled to the free amine of a C-terminal-dipeptidyl component to generate the protected natural product. Deprotection by hydrogenolysis furnishes poststatin.

We also recommend Trading Suppliers and Manufacturers of poststatin (cas 135219-43-1). Pls Click Website Link as below: cas 135219-43-1 suppliers

Prev:poststatin (cas 135219-43-1), a novel inhibitor of bradykinin-degrading enzymes in rat urine
Next:Solid and solution phase synthesis of α-keto amides via azetidinone ring-opening: Application to the synthesis of poststatin (cas 135219-43-1))