A base labile protecting group for peptide synthesis: 2,2 -Bis(4′-nitrophenyl)ethan-1-oxycarbonyl urethanes

Add time:08/09/2019    Source:sciencedirect.com

A base labile urethane (Bnpeoc) group derived from 2,2-bis(4′-nitrophenyl)ethan-1-ol has been developed as an amine protecting group. This protecting group may be cleaved using the reagents DBN, DBU, DBU/HOAc and piperidine. The preparations of Nα-Bnpeoc amino acids and applications to peptide/glycopeptide synthesis are described.

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