Carboxymethyl cyclosophoraoses as a flexible pH-responsive solubilizer for Pindolol (cas 13523-86-9)

Add time:08/11/2019    Source:sciencedirect.com

In the present study, cyclosophoraoses (CyS) (β-1,2 linked cyclic glucans, with glucopyranose units ranging from 17 to 23) isolated from Rhizobium leguminosarum biovar viciae VF-39 were modified with carboxymethyl (CM) groups, and the pH-sensitive complexation of CM CyS with pindolol was investigated. The solubility of pindolol increased 32-fold by its complexation with 5 mM CM CyS at pH 10, whereas it shows no significant change at pH 3. Pindolol, a β-adrenergic blocking agent, has a hydrophobic nature at non-ionized state, and CM CyS could solubilize efficiently pindolol in a high alkaline solution. The carboxymethylation of flexible CyS allows them to present a more suitable cavity for the hydrophobic pindolol at pH 10, which is differentiated from CM β-cyclodextrin (β-CD). It can be interpreted as that the anionic repulsion effectively modulates the flexible and distorted conformation of CyS rather than rigid annular shape of β-CD. Resultingly, the highly solubilized CM CyS/pindolol complex was characterized by UV–vis, T1 relaxation, ROESY, DOSY NMR spectroscopy, FT-IR spectroscopy, SEM, and molecular modeling studies. The antioxidant activity of pindolol was also improved 260% in the complex compared to free pindolol. The use of flexible host molecules with pH-responsive substituents would be applied in the development of smart systems for sensing or in biomedical fields.

We also recommend Trading Suppliers and Manufacturers of Pindolol (cas 13523-86-9). Pls Click Website Link as below: cas 13523-86-9 suppliers

Prev:Effect of single doses of Pindolol (cas 13523-86-9) and d-fenfluramine on flumazenil-induced anxiety in panic disorder patients
Next:Synthesis and crystal structure of (S)-Pindolol (cas 13523-86-9))