Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N′-nitrosonornicotine and N′-nitrosonornicotine-1-N-oxide

Add time:08/17/2019    Source:sciencedirect.com

N′-Nitrosonornicotine (NNN) or N′-nitrosonornicotine-1-N-oxide (NNN-1-N-oxide), one of its metabolites, was added to the drinking water (0.012% for 36 weeks) of groups of male and female F344 rats or to the drinking water (0.016% for 31 weeks) of groups of male and female Syrian golden hamsters. All rats treated with NNN had died after 12 months but 50% of those treated with NNN-1-N-oxide survived for 22 months. NNN induced esophageal tumors in 2324 rats and nasal cavity tumors in 2124 rats. NNN-1-N-oxide induced esophageal tumors in 1024 rats and nasal cavity tumors in 1824 rats. There was no difference in survival rates among hamsters treated with either NNN or NNN-1-N-oxide. NNN induced tracheal tumors in 220 hamsters and nasal cavity tumors in 420 hamsters. NNN-1-N-oxide did not induce respiratory tract tumors in hamsters. These results demonstrate that NNN-1-N-oxide is less carcinogenic than NNN in F344 rats and Syrian golden hamsters.

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