Synthesis of pure methyl [(2S,3R,αR)-1-(3-bromo-4-methoxyphenyl)-3-(α-acetoxy)ethyl-4-oxoazetidin-2-carboxylate] and its enantiomer

Add time:08/13/2019    Source:sciencedirect.com

Synthesis of key intermediates leading to 2-iso-oxacephems was carried out starting from l- and d-threonine. As predicted in our previous paper (Tetrahedron Lett. 1995, 36, 8303–8306) all diastereomers of 2-iso-oxacephems can be prepared from the appropriate enantiomers of the amino acid threonine. The absolute configuration of the 2,3- and α-carbon atoms in the β-lactam structure was determined by X-ray crystallographic studies.

We also recommend Trading Suppliers and Manufacturers of 4-[3-(4-Acetoxy-3-methoxyphenyl)-1-oxo-2-propenyl]morpholine (cas 16562-72-4). Pls Click Website Link as below: cas 16562-72-4 suppliers

Prev:Syntheses of 3-, 4-, and 5-O-feruloylquinic acids
Next:Preparation of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one by microbial conversion)