Design and development of permeation enhancer containing self-nanoemulsifying drug delivery system (SNEDDS) for Ceftriaxone sodium (cas 104376-79-6) improved oral pharmacokinetics
-
Add time:08/10/2019 Source:sciencedirect.com
Ceftriaxone sodium (cas 104376-79-6) cannot be delivered orally due to its lower permeability and gastric instability. Self-nanoemulsifying drug delivery systems (SNEDDS) spontaneously form oil-in-water nanoemulsions and are preferred for oral drug delivery owing to their enhanced permeation capabilities. This study is based on design and development of permeation enhancer containing SNEDDS for oral bioavailability of ceftriaxone sodium. Cinnamon oil, Tween 80 and propylene glycol were selected as oil, surfactant and co-surfactant respectively for the development of SNEDDS on the base of drug solubility and emulsifying ability. Region of self-nanoemulsification was selected through construction of phase diagram. Optimal formulation with best attributes consisted 43.33%, 30% and 26.77% (w/w) oil, surfactant and co-surfactant respectively. SNAC (Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate) was used as permeation enhancer for the development of SNEDDS. The resultant nano-emulsion was investigated for various parameters and stabilities using zetasizer, atomic force microscope, TGA, DSC, FTIR analysis and dilution and thermodynamic stability studies. It was further screened for cellular uptake and in vivo oral bioavailability of the drug. Drug loaded nano-emulsion revealed negatively charged nano size droplets (166–208 nm) and was highly stable against dilution as well as temperature. Drug remained chemically well intact in solubilized from in oil droplets. The drug cellular uptake and in vivo oral bioavailability remarkably increased upon delivery in permeation enhancer containing SNEDDS. Findings of the study confirm the applicability of the designed SNEDDS for enhancing oral bioavailability of Ceftriaxone sodium.
We also recommend Trading Suppliers and Manufacturers of Ceftriaxone sodium (cas 104376-79-6). Pls Click Website Link as below: cas 104376-79-6 suppliers
Prev:Chapter 11 Branched alkylphenols of industrial interest
Next:Effect of ionic liquids, 1-alkyl-4-methylpyridinium bromides on the volumetric, acoustic and viscometric behaviour of aqueous Ceftriaxone sodium (cas 104376-79-6) solutions) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Photocatalytic activity enhanced by synergistic effects of nano-silver and ZnSe quantum dots co-loaded with bulk g-C3N4 for Ceftriaxone sodium (cas 104376-79-6) degradation in aquatic environment08/16/2019
- Influence of alcohols and varying temperatures on the interaction between drug Ceftriaxone sodium (cas 104376-79-6) trihydrate and surfactant: A multi-techniques study08/15/2019
- Bi2WO6 nanoflowers: An efficient visible light photocatalytic activity for Ceftriaxone sodium (cas 104376-79-6) degradation08/14/2019
- Degradation and removal of Ceftriaxone sodium (cas 104376-79-6) in aquatic environment with Bi2WO6/g-C3N4 photocatalyst08/13/2019
- Preparation of a novel Z-scheme KTaO3/FeVO4/Bi2O3 nanocomposite for efficient sonocatalytic degradation of Ceftriaxone sodium (cas 104376-79-6)08/12/2019
- Effect of ionic liquids, 1-alkyl-4-methylpyridinium bromides on the volumetric, acoustic and viscometric behaviour of aqueous Ceftriaxone sodium (cas 104376-79-6) solutions08/11/2019
-
Health and Chemical more >
-
Related Products
- Ceftriaxone Sodium
- Ceftriaxone sodium
- Sodium 2,4-dimethylbenzenesulfonate
- SODIUM γ-FLUORO-β-HYDROXYBUTYRATE
- Sodium ((3-methoxy-1-methyl-3-oxo-1-propenyl)amino)phenylacetate
- Sodium (+)-10-camphorsulfonate
- Sodium (2-carbamoylphenoxy)acetate
- Sodium (2-methyl-4-chlorophenoxy)acetate
- Sodium (6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate pentahydrate
- Sodium (C10-16)alkylbenzenesulfonate