TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma

Add time:08/10/2019    Source:sciencedirect.com

Background & AimsThe thymocyte selection-associated high mobility group box protein (TOX) plays a vital role in T cell development and differentiation, however, its role in T cell exhaustion was unexplored. Here, we aim to investigate the role of TOX in regulating antitumor effect of CD8+ T cells in hepatocellular carcinoma (HCC).

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