Synthesis and characterization of CHITOSAN ASCORBATE (cas 135322-32-6) nanoparticles for therapeutic inhibition for cervical cancer and their in silico modeling
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Add time:08/10/2019 Source:sciencedirect.com
This study focuses on synthesis and characterization of CHITOSAN ASCORBATE (cas 135322-32-6) nanoparticles (CANs) from a salified carboxylate form of chitosan with ascorbic acid. Evident changes were observed in crystallinity and structure of CANs from their parent polymer. CANs exhibited improved antioxidative properties against DPPH, ABTS, and FRAP. In vitro effect of CANs on cervical cancer cells (HeLa) and noncancer human fibroblast cells (WI-38) viability showed portentous toxic effects on cancer cells with reduced viability on increasing CANs concentration. However, no significant effect was observed in the fibroblast cells. Further, in silico docking on cervical cancer protein targets also showed efficient binding.
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