diazipine (cas 135330-18-6), a novel photoaffinity probe for dihydropyridine receptors of calcium channels

Add time:08/10/2019    Source:sciencedirect.com

A new 1,4-dihydropyridine photoaffinity ligand, [3H]diazipine, has been assessed by binding and photolabeling, and compared with a currently used [3H]Diazipine reversibly binds to skeletal muscle Ca2+ channels with a similar affinity of [3H]azidopine, but [3H]diazipine labels the channels two times more efficiently and no release of the incorporated amount is observed after dithiothreitol treatment.

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