Design and synthesis of 2-(1, 3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin-3-yl) acetamide derivatives as potential anticonvulsant agents

Add time:08/10/2019    Source:sciencedirect.com

A series of 2-(1,3-dioxoisoindolin-2-yl)-N-(4-oxo-2-substitutedthiazolidin-3-yl) acetamide derivatives were designed and synthesized using appropriate synthetic route, keeping in view the structural requirement of pharmacophore and evaluated for anticonvulsant activity and CNS depressant activities in mice. The synthesized derivatives were examined in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole (sc-PTZ) induced seizure and neurotoxicity screens and were also evaluated for behavioral activity. All the tested compounds showed protection against MES test indicative of their ability to inhibit the seizure spread.

We also recommend Trading Suppliers and Manufacturers of Acetamide, N-(5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)- (cas 135382-03-5). Pls Click Website Link as below: cas 135382-03-5 suppliers

Prev:Azelastine and Flezelastine (cas 135381-77-0) as reversing agents of multidrug resistance: Pharmacological and molecular studies
Next:clathrodin (cas 135383-64-1), hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels)