Mild and efficient copper-catalyzed N-arylation of alkylamines and N–H heterocycles using an oxime-phosphine oxide ligand

Add time:07/13/2019    Source:sciencedirect.com

A mild and efficient copper-catalyzed system for N-arylation of alkylamines and N–H heterocycles with aryl iodides using a novel, readily prepared and highly stable oxime-functionalized phosphine oxide ligand was developed. The coupling reactions could even be performed in solvent-free conditions with moderate to good yields.

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