Synthesis of the cytotoxic PHYTOSPHINGOSINE (cas 13552-11-9)s and their isomeric analogues

Add time:08/11/2019    Source:sciencedirect.com

A straightforward synthesis of l-lyxo- and l-xylo-phytosphingosine along with their isomeric analogues has been accomplished. The salient features of this approach are the utilization of [3,3]-sigmatropic rearrangements to install a C-N bond and application of a late stage Wittig or OCM reaction to incorporate the hydrophobic chain unit. The final compounds were evaluated regarding their ability to alter both leukaemia and solid tumor cancer cells viability.

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