High-yield synthesis of bioactive Ethyl cinnamate (cas 103-36-6) by enzymatic esterification of cinnamic acid

Add time:08/11/2019    Source:sciencedirect.com

In this paper, Lipozyme TLIM-catalyzed synthesis of Ethyl cinnamate (cas 103-36-6) through esterification of cinnamic acid with ethanol was studied. In order to increase the yield of ethyl cinnamate, several media, including acetone, isooctane, DMSO and solvent-free medium, were investigated in this reaction. The reaction showed a high yield by using isooctane as reaction medium, which was found to be much higher than the yields reported previously. Furthermore, several parameters such as shaking rate, water activity, reaction temperature, substrate molar ratio and enzyme loading had important influences on this reaction. For instance, when temperature increased from 10 to 50 °C, the initial reaction rate increased by 18 times and the yield of ethyl cinnamate increased by 6.2 times. Under the optimum conditions, lipase-catalyzed synthesis of ethyl cinnamate gave a maximum yield of 99%, which was of general interest for developing industrial processes for the preparation of ethyl cinnamate.

We also recommend Trading Suppliers and Manufacturers of Ethyl cinnamate (cas 103-36-6). Pls Click Website Link as below: cas 103-36-6 suppliers

Prev:Visible light-, pH-, and cyclodextrin-responsive AZOBENZENE (cas 103-33-3) functionalized polymeric nanoparticles
Next:Chitosan as biosupport for the MW-assisted synthesis of palladium catalysts and their use in the hydrogenation of Ethyl cinnamate (cas 103-36-6))