Original articleAcetaminophen-induced hepatotoxicity: Preventive effect of trans Anethole (cas 104-46-1)

Add time:08/13/2019    Source:sciencedirect.com

The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-para-benzoquinone imine (NAPQI), which, when reacting with hepatic proteins proved to cause irreversible lesions. Associated with this process, an intense inflammatory process is also evidenced, characterized by the increased cell influx and production/release of inflammatory mediators. Trans anethole, an aromatic compounds has been showed anti-inflammatory efficacy by inhibit the cellular recruitment and synthesis/releases of many proinflammatory mediators such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitrico oxide (NO). The aim of this study is to investigate the effect of trans anethole on some inflammatory parameters that are involved in hepatotoxicity induced by high doses of acetaminophen. Our results demonstrate that treatment with AN at doses 125 and 250 mg/kg once a day for seven days prevented the changes caused by the APAP overdose, showing less intensity in the histological changes (necrosis, size of hepatocyte area and inflammatory infiltration), and corroborating the findings of serum activities of transaminases and phosphatases and the activity of the enzyme myeloperoxidase. In addition, the treatment prevented the up-regulation of proinflammatory mediators such as NO, TNF, IL-1α, MIP-1α and MCP-1 and induced the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10). Thus, our results demonstrate a possible protective effect of trans anethole on the hepatotoxicity induced by APAP.

We also recommend Trading Suppliers and Manufacturers of Anethole (cas 104-46-1). Pls Click Website Link as below: cas 104-46-1 suppliers

Prev:Evaluation of encapsulated Anethole (cas 104-46-1) and carvone in lambs artificially- and naturally-infected with Haemonchus contortus
Next:Supercritical carbon dioxide extraction of trans-Anethole (cas 104-46-1) from Foeniculum vulgare (fennel) seeds: Optimization of operating conditions through response surface methodology and genetic algorithm)