Cu(II) bis(thiosemicarbazone) radiopharmaceutical binding to serum albumin: further definition of species dependence and associated substituent effects

Add time:08/11/2019    Source:sciencedirect.com

IntroductionThe pyruvaldehyde bis(N4-methylthiosemicarbazonato)copper(II) (Cu-PTSM) and diacetyl bis(N4-methylthiosemicarbazonato)copper(II) (Cu-ATSM) radiopharmaceuticals exhibit strong, species-dependent binding to the IIA site of human serum albumin (HSA), while the related ethylglyoxal bis(thiosemicarbazonato)copper(II) (Cu-ETS) radiopharmaceutical appears to exhibit only nonspecific binding to HSA and animal serum albumins.

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