Original articleSynthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol and its enantiomers. Part 1

Add time:08/11/2019    Source:sciencedirect.com

The synthesis of (2RS)-1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol ((RS)-9) and its enantiomers has been described and tested for electrocardiographic, antiarrhythmic, hypotensive and spasmolytic activities as well as for α1-, α2- and β1-adrenoceptors' binding affinities. All compounds significantly decrease systolic and diastolic blood pressure, and possess antiarrhythmic activity and affinity to α1-, α2- and β1-adrenoceptors. The results suggest that the antiarrhythmic and hypotensive effects of these compounds are related to their adrenolytic but not spasmolytic properties.

We also recommend Trading Suppliers and Manufacturers of 3-(4-methoxyphenoxy)propan-1-amine (cas 100841-00-7). Pls Click Website Link as below: cas 100841-00-7 suppliers

Prev:Analyzing the solubility of fluoxetine hydrochloride in supercritical carbon dioxide
Next:Cs2CO3-catalyzed alkylation of indoles with trifluoromethyl ketones)