Original paperSynthesis and analgesic activity of 4-amino-1,2-dihydro-5-(2-hydroxyphenyl)-3H-pyrazol-3-ones and 5-amino-6-(2-hydroxyphenyl)pyrimidin-4(3H)-onesSynthèse et activité analgésique d'amino-4 dihydro-1,2 (hydroxy-2 phényl)-5 pyrazol (3H)-ones-3 et d'amino-5 (hydroxy-2 phényl)-6 pyrimidin (3H)-ones-4

Add time:08/11/2019    Source:sciencedirect.com

4-Amino-1,2-dihydro-5-(2-hydroxyphenyl)-3H-pyrazol-3-ones 2a–c and 5-amino-6-(2-hydroxyphenyl)pyrimidin-4(3H)-ones 3a–f were synthesized from 4-methoxy- and 4-hydroxy-3-nitrocoumarins, and tested for analgesic activity upon oral administration to mice. Most of the compounds prepared exhibited analgesic activity which was superior to that of aminopyrine. In particular, 2a–c and 3a, d showed prominent activity which was 3–4.5 times as potent as that of aminopyrine.

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