VascularHirudin (desulfated, 54–65) contracts canine coronary arteries: Extracellular calcium influx mediates hirudin-induced contractions

Add time:08/11/2019    Source:sciencedirect.com

ObjectiveAlthough the anticoagulatory properties of hirudin are well known, its direct vasoactive effects have not been investigated extensively. Hirudin stimulates nitric oxide and prostacyclin production in noncoronary vascular beds, but its actions on coronary arteries are unknown.

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