Original ArticleSynthesis of novel N-(3-chloro-4-flurophenyl)-2-(5-((3-(4-hydroxy-2, 2-dimethyl-2, 3-dihydrobenzofuran-5-yl)-1-phenyl-1H-pyrazol-4-yl) methylene)-4-oxo-2-thioxothiazolidin-3-yl) acetamides having anti-inflammatory activity

Add time:08/14/2019    Source:sciencedirect.com

Eight derivatives of N-(3-chloro-4-fluorophenyl)-2-(5-((3-(4-hydroxy-2, 2-dimethyl l-2,3-dihydrobenzofuran-5-yl)-1-phenyl-1H-pyrazol-4-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl) acetamide were synthesized by reacting pyrazole having substitutions at 1 and 3 positions (phenyl and benzofuran) with various substituted N-(3-chloro-4-fluorophenyl)-2-(4-oxo-2-thioxothiazolidin-3-yl)acetamides.The series of reactions are depicted in following scheme. The chemical structures of these compounds were confirmed by means of 1H NMR, IR and Mass spectra. The compounds were assayed for anti-inflammatory activity.Among the compounds 10a, 10b and 10d showed significant anti-inflammatory activity, 10c showed moderate anti-inflammatory activity.

We also recommend Trading Suppliers and Manufacturers of N-(3-CHLORO-PHENYL)-2-[(E)-HYDROXYIMINO]-ACETAMIDE (cas 17122-55-3). Pls Click Website Link as below: cas 17122-55-3 suppliers

Prev:Synthesis, characterization, crystal structure and theoretical studies of 4-[(E)-(3-chloro-4-hydroxyphenyl) diazenyl]-1, 5-dimethyl-2-phenyl-1, 2-dihydro-3H-pyrazol-3-one
Next:Versatile reactivity of 3-chloro-2-phenyl-isoindole-1-carbaldehyde: hydrolysis and alkylating rearrangement to 1-amino-4-isochromanones☆)