Inhibition of sexual behavior in female rats by intracerebral injections of Met-enkephalin in combination with an inhibitor of enkephalin degrading enzymes☆

Add time:08/19/2019    Source:sciencedirect.com

Injection of Met-enkephalin, either subcutaneously (10 or 100 μg, s.c.), intracerebroventricularly (100 ng or 1 μg, i.c.v.) or into the mesencephalic central gray (100 ng), had no inhibitory effect on sexual behavior in female rats. If combined with [(R)-3-(N-hydroxy)-carboxamido-2-benzylpropanoyl]-l-alanine (kelatorphan, 5 μg i.c.v.; 1.5 μg in the central gray; 200 μg s.c.), an inhibitor of enkephalin degrading enzymes, however, i.c.v. or central gray (100 ng), but not s.c. (100 μg), injection of Met-enkephalin suppressed the behavior. Injection of Leu-enkephalin, s.c. or i.c.v., alone or in combination with kelatorphan, had no inhibitory effect. Peptidases may rapidly inactivate Met-enkephalin after intracerebral injection and prevent the behavioral effect. Inhibition of sexual behavior by Met-enkehalin may occur during lactation, a physiological state when the behavior is suppressed by an opioid peptide.

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