Studies toward the construction of the allyltrisulfide Component in esperamicin-A1 from 5-ketoshikimic acid derivatives: Part 1
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Add time:08/19/2019 Source:sciencedirect.com
The conversion of keto ester 1, obtained in either enantiomeric form from (−)-quinic acid, to its corresponding enol silyl ether 4 was examined as the first step to construct the allyl trisulfide unit found in esperamicin A1. Under different conditions a very facile dimerization of either 4 or enolate 10 to give compound 14 was observed.
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