Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones as potential TACE inhibitors: Design, synthesis, molecular modeling, and preliminary biological evaluation

Add time:08/12/2019    Source:sciencedirect.com

Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones were synthesized and evaluated for their TACE inhibitory activity. Most of the compounds showed very good TACE inhibitory activity. Docking study clearly indicates importance of the P1′ group of the inhibitor for the TACE inhibitory activity. This work proves that these two classes of molecules could be used as potential leads for the development of TACE inhibitors.

We also recommend Trading Suppliers and Manufacturers of 2-(4-AMINOPHENOXYMETHYL)-2,5,7,8-TETRAMETHYL-4-OXOCHROMAN-6-YL ACETATE (cas 107188-37-4). Pls Click Website Link as below: cas 107188-37-4 suppliers

Prev:Effects of a newly synthesized leukotriene antagonist, NZ-107, on immediate-type hypersensitivity reaction in rats and guinea-pigs
Next:Biodistribution and radiation dosimetry in humans of [11C]FLB 457 (cas 107188-66-9), a positron emission tomography ligand for the extrastriatal dopamine D2 receptor☆)