Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors

Add time:07/12/2019    Source:sciencedirect.com

A series of novel 4-hydroxybenzaldehyde derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were investigated. Most of target compounds had more potent inhibitory activities than the parent compound 4-hydroxybenzaldehyde (IC50 = 1.22 mM). Interestingly, compound 3c bearing a dimethoxyl phosphate was found to be the most potent inhibitor with IC50 value of 0.059 mM. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that compound 3c was a non-competitive inhibitor (KI = 0.0368 mM). In particular, compound 3c showed no side effects at dose of 1600 mg/kg in mice. These results suggested that such compounds might be served as lead compounds for further designing new potential tyrosinase inhibitors.

We also recommend Trading Suppliers and Manufacturers of N,N-DICYCLOHEXYL-2-(2-ETHOXY-4-FORMYL-PHENOXY)-ACETAMIDE (cas 247571-67-1). Pls Click Website Link as below: cas 247571-67-1 suppliers

Prev:Fe-oxidation state in alkali-trisilicate glasses - A Raman spectroscopic study
Next:Iminolactones as tools for inversion of the absolute configuration of α-amino acids and as inhibitors of cancer cell proliferation)