Fluorinated acetylenes, Part 7 [1], Preparation and some reactions of 4,4,4-trifluorobut-2-ynoic acid and 1-phenyl-4,4,4-trifluorobut-2-yn-1-ol (cas 113439-92-2)

Add time:08/12/2019    Source:sciencedirect.com

Treatment of the salt CF3CCLi with alkyl chloroformates affords the compounds CF3CCCO2R (R  Et and CH2Ph) in relatively low yield and with gaseous carbon dioxide yields the acid CF3CCCO2H. Reaction of the acid with diazomethane gives the methyl ester which, with an excess of the reagent, undergoes regiospecific 1,3-dipolar cycloaddition to produce 3-carbomethoxy-4- trifluoromethylpyrazole and hence the 3- and 5-carbomethoxy-1-methyl-4- trifluoromethylpyrazoles. Oxidation of the alcohol CF3CCCH(OH)Ph (active MnO2) affords a 70:23 mixture of 3-benzoyl-2,4-bis(trifluoromethyl)-2-hydroxy-6- phenyl-α-pyran and E-1,3-dibenzoyl-2-trifluoromethylpropene (via the ketone CF3CCCOPh).

We also recommend Trading Suppliers and Manufacturers of 4,4,4-trifluorobut-2-yn-1-ol (cas 113439-92-2). Pls Click Website Link as below: cas 113439-92-2 suppliers

Prev:Preparative synthesis of 2,2-dimethyl-5-(trifluoroacetyl)-1,3-dioxane-4,6-dione (2-trifluoroacetyl Meldrum's acid) and 2,2-dimethyl-6-(trifluoromethyl)-4H-1,3-dioxin-4-one and their synthetic usefulness as (trifluoroacetyl)ketene precursors
Next:Circular dichroism analysis of the Calicheamicin (cas 113440-58-7)-DNA interaction revisited)