Facile preparation of amides from carboxylic acids and amines with ion-supported Ph3P

Add time:08/12/2019    Source:sciencedirect.com

Ion-supported Ph3P, 4-(diphenylphosphino)benzyltrimethylammonium bromide (IS-Ph3P), could be used for the facile amidation of a wide range of carboxylic acids with amines in the presence of bromotrichloromethane to provide the corresponding amides in good yields. In the present reaction, the desired amides were obtained in good yields with high purity by simple extraction of the reaction mixture with diethyl ether or chloroform and subsequent removal of the solvent from the extract. Moreover, ion-supported Ph3PO (IS-Ph3PO), which was a co-product derived from IS-Ph3P in the present reductive condensation, was recovered in high yield and could be reduced to IS-Ph3P for reuse in the same amidation of carboxylic acid.

We also recommend Trading Suppliers and Manufacturers of 4-[(4-bromobenzyl)oxy]-3-methoxybenzoic acid (cas 113457-37-7). Pls Click Website Link as below: cas 113457-37-7 suppliers

Prev:Lactams—I : The synthesis and acid hydrolysis of 4- and 5-substituted 1-benzyl-2-piperidone derivatives☆
Next:Regular paperSynthesis and pharmacological evaluation of 1-methyl-5- [substituted-4(3H)-oxo-1,2,3-benzotriazin-3-yl]-1H-pyrazole-4-acetic acid derivatives)