Combined magnetic porous molecularly imprinted polymers and deep eutectic solvents for efficient and selective extraction of aristolochic acid I and II from rat urine

Add time:08/19/2019    Source:sciencedirect.com

Aristolochia and related plants contain nephrotoxins and mutagens in the form of aristolochic acids (AAs). However, there is still lack of a fast and specific method for monitoring AAs in biological samples. Herein, we synthesized a hybrid magnetic mesoporous carbon-molecularly imprinted polymers ([email protected]) as a novel magnetic solid-phase extraction (MSPE) adsorbent for selective recognition of aristolochic acid I and II from rat urine samples. The choline chloride/glycol-based deep eutectic solvent (DES) and indomethacin were used as the eluent and dummy template molecule accordingly. The morphology, structure property and surface groups of the prepared materials were investigated in sequence, and the optimum conditions of the [email protected] procedure were also optimized well. Results showed that the proposed method had a relatively satisfactory recovery (86.7–94.3%), with low standard deviation (<4.85%) and acceptable correlation coefficients (0.991–0.996). Overall, this work not only provides an inexpensive and eco-friendly method to fabricate [email protected], but also develops a highly promising approach for the detection of aristolochic acid I and II in biological samples.

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