ResearchTissue Engineering—ArticleTethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite

Add time:08/12/2019    Source:sciencedirect.com

Stem cell homing, namely the recruitment of mesenchymal stem cells (MSCs) to injured tissues, is highly effective for bone regeneration in vivo. In order to explore whether the incorporation of mimetic peptide sequences on magnesium-doped (Mg-doped) hydroxyapatite (HA) may regulate the homing of MSCs, and thus induce cell migration to a specific site, we covalently functionalized MgHA disks with two chemotactic/haptotactic factors: either the fibronectin fragment III1-C human (FF III1-C), or the peptide sequence Gly-Arg-Gly-Asp-Ser-Pro-Lys, a fibronectin analog that is able to bind to integrin transmembrane receptors. Preliminary biological evaluation of MSC viability, analyzed by 3-(4,5-dimethyl­thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, suggested that stem cells migrate to the MgHA disks in response to the grafted haptotaxis stimuli.

We also recommend Trading Suppliers and Manufacturers of Lys-arg-asp-ser (cas 116430-80-9). Pls Click Website Link as below: cas 116430-80-9 suppliers

Prev:ArticlesA database of 660 peptide ion cross sections: use of intrinsic size parameters for bona fide predictions of cross sections
Next:Synthesis of N-trityl peptides by the Curtius azide method)