Determination of the active conformation of 6-amino-α-[(4-diphenylmethyl-1-piperazinyl)methyl-9H-purine]-9-ethanol: a positive inotropic agent

Add time:08/13/2019    Source:sciencedirect.com

Conformationally restricted analogues of the positive inotropic agent 1 have been synthesized in order to determine its biologically active conformation. Comparison of the distance maps (as a tool for the allowed conformations) with the biological activity give new insights in the biologically active conformation of this class of positive inotropic agents.

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