Palladium-catalyzed oxidative C–H/C–H cross-couplings of thiazolo[5,4-d]pyrimidine with aromatic (hetero)cycles

Add time:08/13/2019    Source:sciencedirect.com

A novel Pd(II)-catalyzed dehydrogenative cross-coupling reaction of thiazolo[5,4-d]pyrimidine with unactivated (hetero)arenes via C–H bond activation was achieved. This protocol provides a straightforward and operationally simple method for the synthesis of 2-arylsubstituted thiazolo[5,4-d]pyrimidines of interest in pharmaceutical sciences.

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