QSAR on aryl-piperazine derivatives with activity on malaria
-
Add time:07/13/2019 Source:sciencedirect.com
In this work we offer linear regression models on a set of aryl-piperazine derivatives that are obtained by exploring a pool containing 1497 Dragon molecular descriptors, in order to establish the best relationships linking the molecular structure characteristics to their exhibited potencies against chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum parasite. The adjustment of the training molecular set together with the performance achieved during the internal and external validation processes leads to predictive QSAR models. In addition, we derive alternative linear models based on the Coral methodology, which lead to satisfactory results. We apply the final equations to predict the activity on some unknown compounds having non-observed activities.
We also recommend Trading Suppliers and Manufacturers of 1-(4-bromobenzyl)piperazine (cas 5862-39-5). Pls Click Website Link as below: cas 5862-39-5 suppliers
Prev:Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives
Next:Novel push–pull heterocyclic azo disperse dyes containing piperazine moiety: Synthesis, spectral properties, antioxidant activity and dyeing performance on polyester fibers) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Chemiluminescence detection of piperazine designer drugs and related compounds using tris(2,2′-bipyridine)ruthenium(III)07/18/2019
- Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class of σ1 ligands07/17/2019
- Replacement of cardiotoxic aminopiperidine linker with piperazine moiety reduces cardiotoxicity? Mycobacterium tuberculosis novel bacterial topoisomerase inhibitors07/16/2019
- Intracellular pH sensing and targeted imaging of lysosome by a galactosyl naphthalimide-piperazine probe07/15/2019
- Novel push–pull heterocyclic azo disperse dyes containing piperazine moiety: Synthesis, spectral properties, antioxidant activity and dyeing performance on polyester fibers07/14/2019
- Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives07/12/2019
