Ni(II)-catalyzed C(sp2) H alkynylation/annulation cascades: Regioselective access to 3-methyleneisoindoline-1-one using N,S-bidentate auxiliary

Add time:08/13/2019    Source:sciencedirect.com

A nickel(II)-catalyzed alkynylation/annulation of aryl carboxamides assisted by an N, S-bidentate directing group with terminal alkynes is described. This protocol provides an effective method to selectively furnish a series of biologically 3-methyleneisoindolin-1-one derivatives bearing methylthio group. Various carboxamides and terminal alkynes with a number of functional groups were compatible in this reaction to afford the corresponding products in moderate to good yields.

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