N-Arylation of 4-fluoro-5-trimethylsilyl-1H-pyrazole
-
Add time:08/16/2019 Source:sciencedirect.com
The 1,3-dipolar cycloaddition reaction of fluoro(trimethylsilyl)acetylene prepared in situ with an excess of diazomethane smoothly proceeded to give the corresponding 4-fluoro-5-trimethylsilyl-1H-pyrazole in 84% yield. The copper iodide-catalyzed N-arylation of the fluorinated pyrazole with a variety of aryl iodides afforded N-aryl-4-fluoropyrazoles as desilylation products in good to excellent yields.
We also recommend Trading Suppliers and Manufacturers of 4-(Trimethylsilyl)pyridine (cas 18301-46-7). Pls Click Website Link as below: cas 18301-46-7 suppliers
Prev:4-[2-(Trimethylsilyl)ethynyl]benzoates: Synthesis and evaluation for mesomorphic properties of some novel calamitic molecules☆
Next:Straightforward access to tetrahydropyridine and piperidine-fused fluorolactones from pyridines and bis(trimethylsilyl)ketene acetals) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synthesis of oligosaccharides using per-O-trimethylsilyl-glycosyl iodides as glycosyl donor08/19/2019
- Screening of fatty acids, saccharides, and phytochemicals in Jatropha curcas seed kernel as their trimethylsilyl derivatives using gas chromatography/mass spectrometry08/18/2019
- Straightforward access to tetrahydropyridine and piperidine-fused fluorolactones from pyridines and bis(trimethylsilyl)ketene acetals08/17/2019
- 4-[2-(Trimethylsilyl)ethynyl]benzoates: Synthesis and evaluation for mesomorphic properties of some novel calamitic molecules☆08/15/2019
- Synthesis and characterization of photo-crosslinkable 4-styryl-pyridine modified alginate08/14/2019
- Trimethylsilyl imide complexes of tantalum: Can the silyl group be eliminated?08/13/2019
