Increase in cerebral fluids in rats after treatment with hexachlorophane or triethyltin

Add time:08/13/2019    Source:sciencedirect.com

A single intraperitoneal injection of hexachlorophane into rats produced an increase in water in the brain and spinal cord. The additional fluid has been shown to contain sodium and chloride ions. The effect of hexachlorophane on some cerebral intermediary metabolites was also examined. Twenty-four hours after hexachlorophane administration a small increase in cerebral glucose was seen. A single intraperitoneal injection of triethyltin also produced an increase in cerebral water and glucose. Calculations of the glucose concentration present in the additional cerebral water indicates that the extra fluid is derived from either cerebrospinal fluid or plasma.

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