N-trifluoroacetyl-l-norvalyl-l-norvaline cyclohexyl ester as a stationary phase and its interaction with asymmetric solutes

Add time:08/14/2019    Source:sciencedirect.com

N-Trifluoroacetyl-l-norvalyl-l-norvaline1 cyclohexyl ester has been synthesized in high yield and used as a stationary phase for the gas chromatographic enantiomeric separation of N-trifluoroacetyl-d,l-amino acid isopropyl esters. Separation factors and enthalpies of solution have shown a marked increase on solute-solvent interaction to occur for α-amino acids with a four-carbon group on the asymmetric carbon, while the same factors decrease as the substituent grows from one- to three-carbon.Mixtures of d,l-serine and d,l-leucine can now be resolved. Earlier phases have shown significant overlap between d isomers of leucine and serine as well as their l isomers, thereby precluding an accurate qualitative analysis of naturally occurring volatile amino acid derivatives.The phase has also been examined with respect to the separation of a mixture of common amino acids and their enantiomers and was found to be satisfactory.

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