Palladium(II)-catalyzed cyclization of heterocyclic ketene aminals with (E)-ethyl 2,3-diiodoacrylates: selective synthesis of bicyclic pyrroles and bicyclic pyridones

Add time:08/14/2019    Source:sciencedirect.com

A concise and efficient synthesis of novel bicyclic pyrroles has been achieved by PdCl2-catalyzed cyclic condensation of six-membered heterocyclic ketene aminals (HKAs) or seven-membered HKAs with ethyl 2,3-diiodoacrylate and diethyl 2,3-diiodofumarate in the presence of Cs2CO3, respectively. A series of novel bicyclic pyridones have also been obtained via five-membered HKAs with diethyl 2,3-diiodofumarate under the optimized conditions in moderate yields. These reactions are the first application of a transition metal to catalyze the building blocks HKAs to form the bicyclic pyrrole library via condensation reaction.

We also recommend Trading Suppliers and Manufacturers of ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE (cas 107407-80-7). Pls Click Website Link as below: cas 107407-80-7 suppliers

Prev:Original articleSynthesis and fluorescence of new 3-biphenylpyrrolo[1,2-c]pyrimidines
Next:Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus)