Viscometric measurements of dipeptides of alanine in aqueous solutions of antibacterial drug ampicillin at different temperatures

Add time:08/17/2019    Source:sciencedirect.com

The viscosities, ƞ of l-alanyl-l-alanine (Ala-Ala), l-alanyl-l-valine (Ala-Val), l-alanyl-l-leucine (Ala-Leu) with drug ampicillin (AMP) have been measured as a function of temperature at T = (305.15, 310.15 and 315.15) K. The change in viscosity of dipeptides with increase in AMP concentration and temperature is attributed to dipeptide–AMP interactions. The viscosity B-coefficients and viscosity interaction parameters obtained from Jones–Dole equation and transition state theory respectively have been discussed to interpret interactions between ions of dipeptides and ampicillin.

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