Anticonvulsant evaluation and mechanism of action of benzylamino enaminones

Add time:08/14/2019    Source:sciencedirect.com

The mechanism of anticonvulsant action was evaluated for the benzylamino enaminones. The most potent enaminone in this series was the unsubstituted benzylamine analog (30; methyl 4-benzylamino-6-methyl-2-oxocyclohex-3-en-1-oate) which had an oral effective dose (ED50) in rats of 27 mg/kg against maximal electroshock seizures, and a concentration 10-fold less than this dose depressed excitatory synaptic transmission, and action potential firing in the rat brain in vitro.

We also recommend Trading Suppliers and Manufacturers of methyl 2-(benzylamino)acetate (cas 17136-35-5). Pls Click Website Link as below: cas 17136-35-5 suppliers

Prev:Isothermal solubility in supercritical carbon dioxide of solid derivatives of 2,3-dichloronaphthalene-1,4-dione (dichlone): 2-(Benzylamino)-3-chloronaphthalene-1,4-dione and 2-chloro-3-(phenethylamino)naphthalene-1,4-dione
Next:Original article3-Benzylamino-β-carboline derivatives induce apoptosis through G2/M arrest in human carcinoma cells HeLa S-3)