ArticleTolerance to the hypothermic but not to the analgesic effect of [d-Trp11]neurotensin during the semichronic intracerebroventricular infusion of the peptide in rats

Add time:08/18/2019    Source:sciencedirect.com

The peptidase-resistant derivative of neurotensin, [d-Trp11]neurotensin, has been continuously infused intracerebroventricularly (75 ng/h) with an osmotic minipump for 10 days. On several days during this infusion the locomotor activity, the body temperature, the food intake, the body weight, and the nociceptive response in the plantar test were measured. A nonsignificant decrease of body temperature and a sustained analgesic effect were observed at each time considered. The response to a test dose of [d-Trp11]neurotensin (75 ng per rat) injected intracerebroventricularly at the 10th day of the chronic infusion revealed a complete tolerance to its hypothermic effect. Thus, it appears that the analgesic effect of [d-Trp11]neurotensin is independent of a hypothermic or an incapacitating effect of the peptide and does not give rise to tolerance after a 10-day continuous administration, in contrast to the hypothermic effect.

We also recommend Trading Suppliers and Manufacturers of [D- TRP11 ]-NEUROTENSIN (cas 100929-52-0). Pls Click Website Link as below: cas 100929-52-0 suppliers

Prev:ArticleCentrally administered [D-Trp11]neurotensin, as well as neurotensin protected from inactivation by thiorphan, modifies locomotion in rats in a biphasic manner
Next:[d-TRP11]-Neurotensin, unlike α-flupenthixol, may not block amphetamine-induced hyperactivity in rats☆)