Characterization of the selective alkylation site in hemoglobin A by dihydroartemisinin with tandem mass spectrometry
-
Add time:08/18/2019 Source:sciencedirect.com
The reaction between the antimalarial drug dihydroartemisinin (DHA) and hemoglobin A (HbA) was investigated in vitro. A fluorescein-tagged artemisinin analog reacted with HbA and fluorescent HbA-drug adducts could be visualized on SDS-PAGE to confirm stable covalent reaction adducts and necessity of the endoperoxide moiety and Fe(II). Mass spectrometric analyses revealed that DHA favourably alkylated protein part rather than heme and the modification site was identified to be at Tyr35 of the beta globin chain.
We also recommend Trading Suppliers and Manufacturers of hemoglobin Q Thailand (cas 107527-63-9). Pls Click Website Link as below: cas 107527-63-9 suppliers
Prev:Genetic heterogeneity of hemoglobin AEBart's disease: A large cohort data from a single referral center in northeast Thailand
Next:Original ArticleCharacteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Quantitative, single-step dual measurement of hemoglobin A1c and total hemoglobin in human whole blood using a gold sandwich immunochromatographic assay for personalized medicine08/23/2019
- Effects of ambient air pollution on daily hospital admissions for respiratory and cardiovascular diseases in Bangkok, Thailand08/22/2019
- Cord blood screening for α-thalassemia and hemoglobin variants by isoelectric focusing in northern Thai neonates: Correlation with genotypes and hematologic parameters08/21/2019
- Molecular and hematological characteristics of a novel form of α-globin gene triplication: The hemoglobin St.Luke's-Thailand [α95(G2)Pro→Arg] or Hb St. Luke's [A2] HBA208/20/2019
- Original ArticleCharacteristics of scrub typhus, murine typhus, and Q fever among elderly patients: Prolonged prothrombin time as a predictor for severity08/19/2019
- Genetic heterogeneity of hemoglobin AEBart's disease: A large cohort data from a single referral center in northeast Thailand08/17/2019
- Q Sepharose micro-column chromatography: A simple screening method for identifying beta thalassemia traits and hemoglobin E carriers08/16/2019
- Electrospray mass spectrometric characterization of hemoglobin Q (Hb Q-India) and a double mutant hemoglobin S/D in clinical samples08/15/2019
- Hemoglobin Q-Thailand related disorders: Origin, molecular, hematological and diagnostic aspects08/14/2019
