Research paperstefin A (cas 107544-29-6)-functionalized liposomes as a system for cathepsins S and L-targeted drug delivery

Add time:08/14/2019    Source:sciencedirect.com

Proteolytic activity in the tumor microenvironment is one of the key elements supporting tumor development and metastasis. One of the key families of proteases that are overexpressed in various types of cancer and implicated in different stages of tumor progression are cysteine cathepsins. Among them, cathepsins S and L can be secreted into the tumor microenvironment by tumor and/or immune cells, making them promising drug delivery targets. Here we present a new system for cathepsin S/L targeting using a liposomal drug carrier system functionalized with the endogenous cysteine cathepsin inhibitor, stefin A. The selective targeting of cathepsins by stefin A-conjugated liposomes was confirmed in vitro and in vivo, demonstrating the potential of this approach for cancer diagnosis and treatment.

We also recommend Trading Suppliers and Manufacturers of stefin A (cas 107544-29-6). Pls Click Website Link as below: cas 107544-29-6 suppliers

Prev:Properties of YTTRIUM BARIUM COPPER OXIDE (cas 107539-20-8) (YBCO) containing vanadium
Next:Clinical investigationHead and neckstefin A (cas 107544-29-6) and Stefin B: Markers for Prognosis in Operable Squamous Cell Carcinoma of the Head and Neck)