Synthesis of ApoSense compound [18F]2-(5-(dimethylamino)naphthalene-1-sulfonamido)-2-(fluoromethyl)butanoic acid ([18F]NST732) by nucleophilic ring opening of an aziridine precursor

Add time:08/14/2019    Source:sciencedirect.com

IntroductionThe small molecule 2-(5-(dimethylamino)naphthalene-1-sulfonamido)-2-(fluoromethyl)butanoic acid (NST732) is a member of the ApoSense family of compounds, capable of selective targeting, binding and accumulation within cells undergoing apoptotic cell death. It has application in molecular imaging and blood clotting particularly for monitoring antiapoptotic drug treatments. We are investigating a fluorine-18-radiolabeled analog of this compound for positron emission tomography studies.

We also recommend Trading Suppliers and Manufacturers of Butanoic acid 2-(dimethylamino)ethyl ester (cas 16597-65-2). Pls Click Website Link as below: cas 16597-65-2 suppliers

Prev:Regular paperBiosynthesis of GM1b and similar neolactoseries gangliosides by a partially purified chicken skeletal muscle sialyltransferase. Effect of sphingomyelin and acetylcholine☆
Next:Synthesis and polarographic studies of some phenylazo substituted tetra-aza macrocycle complexes)