Metabolism of 2,4′,5-trichlorobiphenyl: Role of the intestinal microflora in the formation of bronchial-seeking methyl sulphone metabolites in mice

Add time:08/17/2019    Source:sciencedirect.com

Groups of germ-free and conventional mice were treated with 2,4′,5-trichlorobiphenyl (triCB) and [35S]cysteine or [35S]methionine, respectively. Control animals received the labelled amino acids only. Conventional mice accumulated significantly more extractable radioactivity both in lung and kidney tissues when compared to germ-free mice. The extracted radioactivity in lung and kidney tissues was shown to be due to the accumulation of methyl-[35S]sulphonyl-triCB. The low radioactivity in lungs of the germ-free mice was also shown to be due to the accumulation of small amounts of the sulphones. The results indicate an involvement of the intestinal flora in the formation of methyl sulphone metabolites of triCB.

We also recommend Trading Suppliers and Manufacturers of 2,4',5-TRICHLOROBIPHENYL (cas 16606-02-3). Pls Click Website Link as below: cas 16606-02-3 suppliers

Prev:Cysteine and methionine—Precursors of methyl sulphone metabolites of 2,4′,5-trichlorobiphenyl in mice☆
Next:Indium(III) complexes with 2-acetylpyridine-derived thiosemicarbazones exhibit cytotoxic activity against human leukemia and solid tumor cell lines)