Alkylation and decarboxylation of ethyl 2-fluoro-3-oxobutanoate as a route to functionalised α-fluoro-ketones

Add time:08/15/2019    Source:sciencedirect.com

Alkylation and decarboxylation of α-fluoro-β-ketoesters such as ethyl 2-fluoro-3-oxobutanoate offers a versatile route to a range of fluoro-ketoalkenes, demonstrating the synthetic utility of using α-fluoro-β-ketoesters as synthons for the preparation of synthetically more sophisticated selectively fluorinated systems.

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