Useful four-carbon synthons en route to monastrol analogs
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Add time:08/15/2019 Source:sciencedirect.com
A simple protocol has been established for the preparation of a family of crystalline N-aryl γ-hydroxycrotonamides, useful four-carbon synthons. These were further elaborated to analogs of monastrol having variant ester sidechains, that were evaluated for their anticancer activity employing the NCI 60 cell line panel.
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