Inhibition of two acetylcholinesterases by the 4-nitrophenyl esters of methyl-, ethyl-, and isopropyl(phenyl)phosphinic acid☆

Add time:08/17/2019    Source:sciencedirect.com

The inhibition of eel acetylcholinesterase and bovine erythrocyte acetylcholinesterase by the 4-nitrophenyl esters of methyl-, ethyl-, and isopropyl(phenyl)phosphinic acid (MPP, EPP, and IPP, respectively) was investigated at pH 6.90 in 0.067 M phosphate buffer (25.0°C) using stopped-flow instrumentation and automated data processing. Our evaluation of the dissociation constant, Kd, the unimolecular bonding rate constant, k2, and the bimolecular reaction constant, ki, are the first reported values for these constants for a homologous series of this class of organophosphorus compounds. The largest k1 value (29,428 M−1 sec−1) was observed for the reaction of eel acetylcholinesterase with 4-nitrophenyl methyl(phenyl)phosphinate. The smallest ki value (9.6 M−1 sec−1) was observed for the reaction of bovine erythrocyte acetylcholinesterase with 4-nitrophenyl isopropyl(phenyl)phosphinate.

We also recommend Trading Suppliers and Manufacturers of Carbonic acid phenyl(4-nitrophenyl) ester (cas 17175-11-0). Pls Click Website Link as below: cas 17175-11-0 suppliers

Prev:Eel acetylcholinesterase studies with the 4-nitrophenyl esters of monochloro-, dichloro-, and trichloromethyl(phenyl)phosphinic acid☆
Next:Synthesis of (E)-α,β-unsaturated carboxylic esters derivatives from cyanoacetic acid via promiscuous enzyme-promoted cascade esterification/Knoevenagel reaction)