Antithrombin III: structural and functional aspects
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Add time:08/15/2019 Source:sciencedirect.com
Antithrombin III is a plasma gylcoprotein responsible for thrombin inhibition in the blood coagulation cascade. The X-ray structure of its cleaved form has been determined and refined to 3.2 Å resolution. The overall topology is similar to that of ω1-antitrypsin, another member of the serpin (serine protease inhibitor) superfamily. The biological activity of antithrombin III is mediated by a polysaccharide, heparin. The binding site of this effector is described. A possible structural transition from the native to the cleaved structure is discussed.
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