Enantiomeric synthesis of l- (or 1S,2R,3S,5S)-bicarbocyclic[3.1.0] nucleosides

Add time:08/14/2019    Source:sciencedirect.com

The total synthesis of l- (or 1S,2R,3S,5S)-bicarbocyclic nucleosides (8–15) has been accomplished. The key intermediate 3 was synthesized in two steps from the known chiral compound 1 through a stereoselective cyclopropanation under Furukawa conditions and its X-ray structure has been determined. The derivative 4 was utilized to obtain thymine derivative (8). Amino exocyclic pyrimidine (9–12) and purine (13–15) bicarbocyclic l-nucleosides were obtained from the (1S,2R,3S,5S)-2-(3-aminobicyclo[3.1.0]hex-2-yl)ethanol (7).

We also recommend Trading Suppliers and Manufacturers of [(1S,2R,5S)-2-Isopropyl-5-methylcyclohexyl]6-O-β-D-glucopyranosyl-β-D-glucopyranoside (cas 135636-00-9). Pls Click Website Link as below: cas 135636-00-9 suppliers

Prev:Zircon geochronology and Sm–Nd isotopic study: Further constraints for the Archean and Paleoproterozoic geodynamical evolution of the southeastern Guiana Shield, north of Amazonian Craton, Brazil
Next:Synthesis of spirocyclic β-methylene-γ-lactone utilizing hydroxymethylation of functionalized allylsilane)