Synthesis of new fluorinated synthons: (E and Z) ClFCCFI and (E and Z) BrFCCFI☆

Add time:08/17/2019    Source:sciencedirect.com

(E)- and (Z)-1,2-difluoro-1-(trimethylsilyl)ethenes are readily prepared from trifluorovinyl(trimethyl)silane. These hydro compounds are readily metalated at low temperatures to give a stable lithium intermediate which can be captured by tri-n-butylstannyl chloride to give (E)- and (Z)-1,2-difluoro-2-trimethylsilyl-1-(tri-n-butylstannyl)ethenes. The stannyl derivatives can be halogenated stereospecifically with iodobenzene dichloride and NBS to provide the (E)- and (Z)-1-halo-1,2-difluoro-2-(trimethylsilyl)ethenes. The vinylsilanes can be readily converted in two steps to the titled synthons, (E)- and (Z)-2-halo-1,2-difluoro-1-iodoethenes by literature procedures. (E)- and (Z)-1,2-difluoro-1-(trimethylsilyl)ethenes boil ∼30 °C apart and are readily separated by fractional distillation.

We also recommend Trading Suppliers and Manufacturers of (E and Z)-3-Ethylidenecyclohexene (cas 16631-62-2). Pls Click Website Link as below: cas 16631-62-2 suppliers

Prev:Research PaperThermodynamic analysis of low GWP alternatives to HFC-245fa in high-temperature heat pumps: HCFO-1224yd(Z), HCFO-1233zd(E) and HFO-1336mzz(Z)
Next:Chlorination of 5-Nitro-6-methyluracil (cas 16632-21-6) and its N(1),N(3)-dimethyl analogue with molecular chlorine)