Preparation of novel pyrrol-2-one derivatives via an effective synthesis of new oxazole scaffold

Add time:07/14/2019    Source:sciencedirect.com

A convenient procedure for the preparation of oxazole and pyrrole derivatives is described. 2-Amino-1,3-oxazol-2-ones 3a,b were first synthesized from the cyclocondensation reactions of cyanamide (2) with 4-ethoxycarbonyl-5-aryl-2,3-furandione 1a,b, and then new pyrrol-2-ones 5 were synthesized from the reaction of the compounds 3 with various aromatic amines 4.

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